BackgroundDifferent histone post-translational modifications (PTMs) are crucial in the regulation of chromatin. including methylations of H3 at Lysine 4 by the MLL complex. A relevant issue is how this is causally correlated to the binding of specific transcription factors (TFs) in regulatory regions. NF-Y is a TF that regulates 30% of mammalian promoters containing the widespread CCA... https://herbsdailyes.shop/product-category/fruit-formulas/
NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.
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